RB regulates pancreas development by stabilizing Pdx1
نویسندگان
چکیده
منابع مشابه
RB regulates pancreas development by stabilizing Pdx1.
RB is a key substrate of Cdks and an important regulator of the mammalian cell cycle. RB either represses E2Fs that promote cell proliferation or enhances the activity of cell-specific factors that promote differentiation, although the mechanism that facilitates this dual interaction is unclear. Here, we demonstrate that RB associates with and stabilizes pancreatic duodenal homeobox-1 (Pdx-1) t...
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Cell division and cell differentiation are intricately regulated processes vital to organ development. Cyclin-dependent kinases (Cdks) are master regulators of the cell cycle that orchestrate the cell division and differentiation programs. Cdk1 is essential to drive cell division and is required for the first embryonic divisions, whereas Cdks 2, 4 and 6 are dispensable for organogenesis but vit...
متن کاملDynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.
The onset of pancreas development in the foregut endoderm is marked by activation of the homeobox gene Pdx1 (IPF1). Pdx1 is essential for the expansion of the pancreatic primordium and the development of endocrine islets. The control of Pdx1 expression has been only partially elucidated. We demonstrate here that the winged-helix transcription factors Foxa1 and Foxa2 co-occupy multiple regulator...
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ownloade ophagy is a protective mechanism that renders cells viable in stressful conditions. Emerging evidence ts that this cellular process is also a tumor suppressor pathway. Previous studies showed that cyclindent kinase inhibitors (CDKI) induce autophagy. Whether retinoblastoma protein (RB), a key tumor ssor and downstream target of CDKIs, induces autophagy is not clear. Here, we show that ...
متن کاملPancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood.
Pancreas duodenum homeobox-1 (PDX-1) (also known as insulin promoter factor-1, islet/duodenum homeobox-1, somatostatin transactivating factor-1, insulin upstream factor-1 and glucose-sensitive factor) is a transcription factor encoded by a Hox-like homeodomain gene. In humans and other animal species, the embryonic development of the pancreas requires PDX-1, as demonstrated by the identificatio...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2011
ISSN: 0261-4189
DOI: 10.1038/emboj.2011.57